منابع مشابه
HIV Persistence and Viral Reservoirs
Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting memory CD4 T-cells are an important cellular reservoir, and the central nervous system (CNS) an important anatomical reservoir for HIV-1 infection. The overall aim of this the...
متن کاملHIV reservoirs: pathogenesis and obstacles to viral eradication and cure.
Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved. However, ART alone cannot eradicate HIV in infected individuals and this impedime...
متن کاملInitiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation
INTRODUCTION Colonic infiltration by HIV occurs soon after infection, establishing a persistent viral reservoir and a barrier to cure. We investigated virologic and immunologic correlates of detectable colonic HIV RNA during acute HIV infection (AHI) and their response to antiretroviral treatment (ART). METHODS From 49,458 samples screened for HIV, 74 participants were enrolled during AHI and...
متن کاملVirus ecology: studying animal reservoirs to understand viral emergence.
Ten years after the SARS epidemic, zoonotic and emerging viruses have become a growing field of research. Some remarkable novel virus descriptions in animals have demonstrated how ignorant we are of the diversity of viruses around us. In our efforts to delineate viral origins we may have to re-assess our concept of reservoir. In many instances, we are mixing up ecological and epidemiological im...
متن کاملIdentification and characterization of HIV-1 latent viral reservoirs in peripheral blood.
Plasma viral load and CD4 counts are effective for clinical monitoring, but they do not give a full representation of HIV-1 quasispecies in cellular reservoirs, the major repository of replication-competent HIV-1 in infected individuals. We sought to develop a diagnostic system that might stimulate the replication-competent HIV-1 reservoirs for enhanced clinical monitoring, including selection ...
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ژورنال
عنوان ژورنال: Current Opinion in HIV and AIDS
سال: 2016
ISSN: 1746-630X
DOI: 10.1097/coh.0000000000000230